In this short video, Professor Diana Brozić presents the key findings of her study regarding her research on canine chronic enteropathies (CE).
Research Summary: This study aimed to determine the effects of disease remission in food-responsive chronic enteropathies in dogs fed a hydrolysed protein hypoallergenic extruded diet or a homemade novel protein diet, on oxidative and antioxidant status monitored through the concentration of malondialdehyde, superoxide dismutase, and glutathione peroxidase, and protein fractions in serum. We hypothesize a difference in oxidative and antioxidative status in symptomatic dogs versus dogs in remission state, alongside marked differences in protein fractions in plasma. We found that the markers of oxidative stress may not directly reflect the clinical improvements observed in patients. Additionally, we observed a depletion of antioxidant capacity in dogs with food-responsive chronic enteropathies. In the remission state, the alpha-1 and beta-2 globulin fractions were reduced, indicating a reduction in inflammation. In contrast, the gamma globulin fraction was elevated after remission (no hypergammaglobulinemia), possibly due to the intestinal loss of gamma globulins during the symptomatic phase of disease, following normalization in the remission state. Early phase of clinician remission in dogs with chronic enteropathies is marked by unstable antioxidative and protein patterns, therefore, dietary approaches should be further evaluated to support this critical stage in patient stabilisation.
